
The broad goal of our research is the development of
next-generation nucleic acids and synthetic cells
for biology and medicine

We are an interdisciplinary research group utilising techniques from organic/inorganic synthesis, chemical biology, biochemistry, synthetic biology, and molecular and cellular biology.
News
2025
- November: Mike gave a Build-A-Cell webinar on the group’s synthetic cell research, which you can watch on YouTube
- November: Welcome to Beth Langford, who is undertaking a rotation project in the group as part of the CDT in Accelerated Medicines Design and Development
- October: Congratulations to Ellen for passing her DPhil viva – we’re excited that Ellen is staying in the group as a Postdoc on an EPSRC Postdoctoral Pathway Fellowship!
- September: Also, welcome to our new Master’s students Jing, Tianyi, and Yifan!
- September: Welcome to Ann-Céline Clabout, a new PhD student in the group from the Engineering Solutions for AMR CDT!
- September: Ellen’s paper on “Magnetic activation of spherical nucleic acids enables the remote control of synthetic cells” has been published in Nature Chemistry! Along with a Times article 🙂
- August: Charlie worked on a collaborative paper with the group of Allen Liu on “Strategies and applications of synthetic cell communication“, just published in Nature Chemical Biology!
- August: Disha’s paper on “Harnessing BET-Bromodomain Assisted Nuclear Import for Targeted Subcellular Localization and Enhanced Efficacy of Antisense Oligonucleotides” has been published in JACS!
- July: Disha’s paper on “DNA-Programmable Protein Degradation: Dynamic Control of Proteolysis-Targeting Chimera Activity via DNA Hybridization and Strand Displacement” has been published in JACS Au!
- July: Mike was invited to contribute to the USA National Academies committee meeting on the “Environmental, Biosafety, and Biosecurity Considerations for Synthetic Cell Research and Development“
- June: Disha’s paper on “Engineering antisense oligonucleotides for targeted mRNA degradation through lysosomal trafficking” has been published in Chemical Science!
- April: Mike has been highlighted as a 2024 Rising Star in Biological, Medicinal, and Pharmaceutical Chemistry by ACS Bio & Med Chem Au
- March: Welcome to visiting students Leo (PhD, Italy) and Rosario (Master’s, Spain)!
- March: A third preprint led by Disha is now online: “DNA-programmable Protein Degradation: Dynamic Control of PROTAC Activity via DNA Hybridization and Strand Displacement“
- March: Here’s a new preprint from the group on “Engineering antisense oligonucleotides for targeted mRNA degradation through lysosomal trafficking” (Led by Disha)!
University College London
Christopher Ingold Building
Department of Chemistry
University College London
20 Gordon Street
London
WC1H 0AJ
In addition, part of our group is still based within the Chemistry Research Laboratory, Department of Chemistry, University of Oxford – Directions and Maps